ABSTRACT
Abstract: Multinucleate cell angiohistiocytoma is a rare idiopathic benign fibrohistiocytic and vascular proliferation usually presenting as multiple asymptomatic papules, red to violaceous in colour, primarily located on the extremities of middle-aged females. This entity is probably underdiagnosed due to the lack of recognition by clinicians and pathologists. We describe a patient with a multinucleate cell angiohistiocytoma of the face, a less frequent localization, in order to increase awareness of this entity and elucidate its clinical, histopathological, and immunohistochemistry features.
Subject(s)
Humans , Female , Middle Aged , Skin Neoplasms/pathology , Facial Neoplasms/pathology , Histiocytoma, Benign Fibrous/pathology , Skin Neoplasms/diagnosis , Biopsy , Facial Neoplasms/diagnosis , Cheek/pathology , Histiocytoma, Benign Fibrous/diagnosis , Erythema/pathologyABSTRACT
Abstract: Lupus miliaris disseminatus faciei is a rare inflammatory dermatosis of unknown etiology that primarily affects young adults. Clinically, it is characterized by an asymptomatic papular eruption mainly involving the central face, typically on and around the eyelids. Characteristic histopathological features include dermal epithelioid cell granulomas with central necrosis and surrounding lymphocytic infiltrate with multinucleate giant cells. Lupus miliaris disseminatus faciei has a spontaneously resolving course, yet can be cosmetically debilitating given the location and potential for scarring. Treatment is difficult and there is a lack of controlled studies. We report a new case of lupus miliaris disseminatus faciei successfully treated with minocycline and systemic steroids, and briefly discuss its nosology and therapeutic options.
Subject(s)
Humans , Female , Adult , Facial Dermatoses/pathology , Granuloma/pathology , Biopsy , Prednisolone/therapeutic use , Epithelioid Cells/pathology , Treatment Outcome , Facial Dermatoses/drug therapy , Glucocorticoids/therapeutic use , Granuloma/drug therapy , NecrosisABSTRACT
Abstract: Ashy dermatosis is a rare condition, of unknown aetiology, in which mucous membranes are typically spared. The authors report the case of a 57-year-old female with a history of asymptomatic gray-bluish macules located on the trunk and oral mucosa. There were no relief changes on examination. Skin biopsies from the oral mucosa and trunk were performed and both were compatible with ashy dermatosis. The patient started treatment with oral clofazimine but due to the absence of clinical improvement the drug was discontinued three months later. This case report illustrates an atypical case of ashy dermatosis owing to the involvement of mucous membranes, which is rarely described in the literature.